Understanding and Curing Spiritual Depression So what is spiritual depression? Spiritual depression, like any other form of depression, deals with feelings of sadness, weakness, lack of motivation, lack of positive outlook or even physical illness. Spiritual depression only differs in that these feelings are typically associated with ones perception of themselves in a spiritual regard. For instance, losing faith in your god or feeling that you have lost your way and have failed in the following of your religious beliefs. These are concepts that represent possible causes for spiritual depression.